Drug residues in foods [Recurso electrónico] : pharmacology, food safety, and analysis / Nikolaos A. Botsoglou, Dimitrios J. Fletouris.

Disponible también en formato impreso.

Incluye referencias bibliográficas.

Part I: Drugs in food-producing animals.--

1. A general view of drug usage.--
1.1 Introduction.--
1.2 Classification of potentially used drugs.--
1.3 Extent of drug use.--
1.4 Methods of medication.--
1.5 Dosage forms and routes of administration.--
References.--

2. Some pharmacokinetic considerations.--
2.1 Fate of drugs in terrestrial species.--
2.2 Fate of drugs in aquatic species.--
References

3. Antibacterial drugs.--
3.1 Aminoglycosides and aminocyclitols.--
3.2 Amphenicols.--
3.3 β-Lactams.--
3.4 Macrolides and lincosamides.--
3.5 Nitrofurans.--
3.6 Quinolones.--
3.7 Sulfonamides and diaminopyrimidine potentiators.--
3.8 Tetracyclines.--
3.9 Miscellaneous.--
References.--

4. Antihelminthic drugs.--
4.1 Benzimidazoles.--
4.2 Imidazothiazoles.--
4.3 Organophosphates.--
4.4 Tetrahydropyrimidines.--
4.5 Salicylanilides.--
4.6 - Substituted Phenols.--
4.7 Macroeyelic Lactones.--
4.8 Piperazine Derivatives.--
4.9 Miscellaneous.--
References.--

5. Anticoccidial and other antiprotozoal drugs.--
5.1 Benzamides.--
5.2 Carbanilides.--
5.3 Nitroimidazoles.--
5.4 Polyether Ionophore Antibiotics.--
5.5 Quinolone Derivatives.--
5.6 Triazines.--
5.7 Miscellaneous.--
References.--

6. Antimicrobial growth promoters.--
6.1 Organic arsenicals.--
6.2 Peptide antibiotics.--
6.3 Quinoxaline-1.4-Dioxides.--
6.4 Miscellaneous.--
References.--

7. Anabolic hormonal-type growth promoters.--
7.1 Endogenous sex steroids.--
7.2 Steroidal compounds not occurring naturally.--
7.3 Nonsteroidal compounds not occurring naturally.--
7.4 Polypeptide hormones.--
References.--

8. Other drugs.--
8.1 - Antifungal drugs.--
8.2 β-Adrenergic agonists.--
8.3 Corticosteroids.--
8.4 Diuretic drugs.--
8.5 Dye drugs.--
8.6 Nonsteroidal anti-inflammatory drugs.--
8.7 Sedatives and β-Blockers.--
8.8 Thyreostatic Drugs.--
References

9. Benefits and risks of drug usage.--
9.1 Benefits to animals, man and the environment.--
9.2 Risks related to food contamination and bacterial resistance.--
References.--


Paart II: Residues in food.--

10. Drug residues and public health.--
10.1 Types of residues and their toxicological significance.--
10.2 Toxicological hazards.--
10.3 Pharmacological hazards.--
10.4 Microbiological hazards.--
10.5 Immunological Hazards.--
10.6 Enzyme Perturbation Hazards.--
References.--

11. Safety assessment and control of residues.--
11.1 A general overview.--
11.2 Regulatory outline by international organizations.--
11.3 Regulatory outline in the U.S.--
11.4 Regulatory outline in the EU.--
11.5 Regulatory outline in Australia.--
11.6 Regulatory outline in Canada.--
11.7 Regulatory outline in Japan.--
References.--

12. Global harmonization of regulatory requirements.--
12.1 Acceptable daily intake.--
12.2 - Assignment of the ADI to MRL/Tolerance.--
12.3 - Analytical methods for residues determination.--
12.4 Compliance of legislation with toxicology.--
12.5 Harmonization Initiatives.--
References.--

13. INCIDENCE OF VIOLATIVE RESIDUES IN FOOD.--
13.1 Residues in the U.S.--
13.2 Residues in the European Union.--
13.3 Residues in Australia.--
13.4 - Residues in other countries.--
References.--

14. Factors influencing the occurrence of residues in foods.--
14.1 Management.--
14.2 Biological processes.--
References.--

15. Costs of residues in the livestock industry.--
References.--

16. Residue avoidance management.--
References.--

17. Stability of residues during food processing.--
17.1 Residues of antibacterial drugs.--
17.2 Residues of anthelminthic drugs.--
17.3 Residues of anticoccidial drugs.--
17.4 Residues of antimicrobial growth promoters.--
17.5 Residues of anabolic hormonal-type growth promoters: somidobone.--
17.6 Residues of β-Adrenergic agonists: clenbuterol.--
17.7 Residues of sedative drugs.--
17.8 Conclusion.--
References.--

18. Consumer perceptions and concerns.--
References.--


Part III: Analysis of drug residues.--

19. The analytical challenge.--
References.--

20. Sample preparation.--
20.1 Selection of basic analytical equipment.--
20.2 Sampling/storage.--
20.3 Protein denaturation.--
20.4 Extraction/cleanup.--
References.--

21. Derivatization.--
21.1 Fluorescence derivatization.--
21.2 Ultraviolet-visible derivatization.--
21.3 Enzymatic derivatization.--
214 Photochemical derivatization.--
References.--

22. Separation.--
22.1 Liquid chromatography.--
22.2 Gas chromatography.--
22.3 Thin-Layer chromatography.--
22.4 Supercritical fluid chromatography.--
22.5 Capillary electrophoresis.--
22.6 Multidimensional separation.--
References.--

23. Detection.--
23.1 Microbiological techniques.--
23.2 Immunochemical techniques.--
23.3 Physicochemical techniques.--
References.--

24. Confirmation.--
24.1 Liquid chromatography/capillary electrophoresis-diode array detection techniques.--
242 Gas chromatography-mass spectrometry techniques.--
243 Thin layer chromatography-mass spectrometry techniques .--
244 Liquid chromatography-mass spectrometry techniques.--
245 Gas chromatography-infrared spectroscopy techniques.--
246 Liquid chromatography-infrared spectroscopy techniques.--
References.--

25. Validation.--
25.1 Parameters for method validation.--
25.2 Procedures for method validation.--
References.--

26. Analytical strategy.--
26.1 Classification of methods for regulatory purposes.--
262 Quality criteria for selecting an analytical method.--
263 Interpretation of analytical results.--
264 Strategies for monitoring food supply for drug residues.--
References.--

27. Microbiological methods.--
27.1 Assay formats.--

27.2 Applications.--
References.--

28. Immunochemical methods.--
28.1 Antigen development.--
282 - Antibody development.--
28.3 Reagent formatting.--
284 Applications.--
References.

29. Physicochemical methods.--
29.1 Aminoglycosides and aminocyclitols.--
29.2 Amphenicols.--
29.3 β-Lactam antibiotics.--
29.4 Macrolides and lincosamides.--
29.5 Nitrofuran antibacterials.--
29.6 Quinolones.--
29.7 Sulfonamides and diaminopyrimidine potentiators.--
29.8 Tetracyclines.--
29.9 Miscellaneous antibacterials.--
29.10 Anthelminthic drugs.--
29.11 Anticoccidial and other antiprotozoal drugs.--
29.12 Antimicrobial growth promoters.--
29.13 Anabolic hormonal-type growth promoters.--
29.14 β-Adrenergic agonists.--
29.15 Dye drugs.--
29.16 Sedatives and β-blockers.--
29.17 Corticosteroids.--
29.18 Diuretic and nonsteroidal anti-inflammatory drugs.--
29.19 Thyreostatic drugs.--
References.--

30. Future trends.

Área de Ciencias de la Salud

Texto en Inglés.