TY  - BOOK
AU  - Schwartz,Gary K.
TI  - Combination cancer therapy: modulators and potentiators 
T2  - Cancer drug discovery and development
SN  - 1588292002
AV  - RC271.C5 O4 2005
PY  - 2005///
CY  - Totowa, N.J.
PB  - Humana
KW  - Drug interactions
KW  - Apoptosis
KW  - Cancer
KW  - Chemotherapy
KW  - Cáncer
KW  - Quimioterapia
KW  - Tratamiento
KW  - Oncología
KW  - Medicina
N1  - Incluye referencias bibliográficas; 1. Targeting of the EGFR as a modulator of cancer chemotherapy.-- 
2. Cyclin-dependent kinase inhibitors in combination chemotherapy.-- 
3. Development of protein kinase C and cyclin-dependent kinase inhibitors as potentiators of cytotoxic drug action in leukemia.-- 
4. Carboxyamidotriazole, an inhibitor of nonvoltage-operated calcium entry: single-agent and combination therapy for ovarian carcinoma.-- 
5. Targeted F-particle therapy: a rational approach to drug development in hematologic diseases and solid tumors.-- 
6. Pharmacological modulation of fluoropyrimidines: building on the lessons of the past.-- 
7. Development of inhibitors of HER2 with taxanes: new directions in breast cancer therapy.-- 
8 Targeting NF-PB to increase the activity of cisplatin in solid tumors.-- 
9. Combinations of chemotherapy and G3139, an antisense Bcl-2 oligonucleotide.-- 
10. Use of animal models to evaluate signal transduction inhibitors as modulators of cytotoxic therapy.

; Salud
N2  - Expert physician-scientists and clinicians review those combinations of novel target agents classic chemotherapies that hold the most promise for the future of medical oncology, and detail their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatments in cancer therapy.


UR  - https://web.archive.org/web/20240306235941/https://media.springernature.com/full/springer-static/cover-hires/book/978-1-59259-864-9?as=webp
UR  - https://books.google.bj/books?id=4K0si9SvzRIC&printsec=frontcover&hl=es
UR  - https://web.archive.org/web/20240306235935/https://link.springer.com/book/10.1385/1592598641#toc
UR  - https://web.archive.org/web/20240307001045/https://link.springer.com/content/pdf/bfm:978-1-59259-864-9/1?pdf
ER  -