Chromatographic analysis of pharmaceuticals / edición, John A. Adamovics

Colaborador(es):

Adamovics, John A [ed.]

Tipo de material: Texto

TextoIdioma: Inglés Series Chromatographic science ; 74Detalles de publicación: New York, NY : Marcel Dekker, 1997Edición: 2a edDescripción: x, 527 p. : il. ; 24 cmISBN:

0824797760
9780824797768

Tema(s):

Clasificación CDD:

615/.1901

Clasificación LoC:

RS189.5 .C4 1997

Contenidos parciales:

1. REGULATORY CONSIDERATIONS FOR THE CHROMATOGRAPHER (John A. Adamovics).-- I. Introduction.-- II. Impurities.-- III. Stability.-- IV. Method Validation.-- V. System Suitability Testing.-- VI. Product Testing.-- VII. Conclusion.-- References.-- 2. SAMPLE PRETREATMENT (John A. Adamovics).-- I. Introduction.-- II. Sampling.-- III. Sample Preparation Techniques.-- IV. Conclusions.-- References.-- 3. PLANAR CHROMATOGRAPHY (John A. Adamovics and James C. Eschbach).-- I. Introduction.-- II. Materials and Techniques.-- III. Detection.-- IV. Methods Development.-- V. Conclusion.-- References.-- 4. GAS CHROMATOGRAPHY (John A. Adamovics and James C. Eschbach).-- I. Introduction.-- II. Stationary Phases.-- III. Hardware.-- IV. Applications.-- V. Conclusion.-- References.-- 5. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (John A. Adamovics and David L. Farb).-- I. Introduction.-- II. Sorbents.-- III. Instrumentation.-- IV. Method Development.-- V. Conclusion.-- References.-- 6. CAPILLARY ELECTROPHORESIS (Shelley R. Rabel and John F. Stobaugh).-- 1. Introduction.-- II. Capillary Electrophoresis Formats.-- III. Instrumentation.-- IV. Methods Development.-- V. Conclusion.-- References.-- 7. SUPERCRITICAL FLUID CHROMATOGRAPHY OF BULK AND FORMULATED PHARMACEUTICALS (James T. Stewart and Nirdosh K. Jagota).-- 1. Introduction.-- II. Hardware.-- III. Application of SFC to Selected Bulk and Formulated Pharmaceuticals.-- IV. Conclusions.-- V. References.-- 8. APPLICATIONS (John A. Adamovics).-- I. Introduction.-- II. Abbreviations.-- III. Table of Analysis.-- References.

Resumen: PREFACE: The first edition of Chromatographic Analysis of Pharmaceuticals was published in 1990. The past years have allowed me to evaluate leads that I uncovered during the researching of the first edition, such as the first pub lished example of the application of chromatography to pharmaceutical analysis of medicinal plants. This and other examples are found in a rela tively rare book, Uber Kapillaranalyse und ihre Anwendung in Pharmazeu tichen Laboratorium (Leipzig, 1992), by H. Platz. Capillary analysis, the chromatographic technique used, was developed by Friedlieb Runge in the mid-1850s and was later refined by Friedrich Goppelsroeder. The principle of the analysis was that substances were absorbed on filter paper directly from the solutions in which they were dissolved; they then migrated to different points on the filter paper. Capillary analysis differed from paper chromatography in that no developing solvent was used. We find that, from these humble beginnings 150 years ago, the direct descendant of this technique, paper chromatography, is still widely used in evaluating radio pharmaceuticals. This second edition updates and expands on coverage of the topics in the first edition. It should appeal to chemists and biochemists in pharma ceutics and biotechnology responsible for analysis of pharmaceuticals. As in the first edition, this book focuses on analysis of bulk and formulated drug products, and not on analysis of drugs in biological fluids. The overall organization of the first edition-a series of chapters on regulatory considerations, sample treatment (manual/robotic), and chro matographic methods (TLC, GC, HPLC), followed by an applications sec tion-has been maintained. To provide a more coherent structure to this edition, the robotics and sample treatment chapters have been consolidated, as have the chapters on gas chromatography and headspace analysis. This edition includes two new chapters, on capillary electrophoresis, and super critical fluid chromatography. These new chapters discuss the hardware behind the technique, followed by their respective approaches to methods development along with numerous examples. All the chapters have been updated with relevant information on proteinaceous pharmaceuticals. The applications chapter has been updated to include chromatographic methods from the Chinese Pharmacopoeia and updates from U.S. Pharmacopeia 23 and from the British and European Pharmacopoeias. Methods developed by instrument and column manufacturers are also included in an extensive table, as are up-to-date references from the chromatographic literature. The suggestions of reviewers of the first edition have been incorpo rated into this edition whenever possible. This work could not have been completed in a timely manner without the cooperation of the contributors, to whom I am very grateful. John A. Adamovics.

Etiquetas de esta biblioteca: No hay etiquetas de esta biblioteca para este título. Ingresar para agregar etiquetas.

Existencias ( 1 )
Notas de título ( 6 )

Existencias
Tipo de ítem	Biblioteca actual	Colección	Signatura topográfica	Estado	Notas	Fecha de vencimiento	Código de barras
01-Préstamo Interno (Libros)	Biblioteca de Alimentos	Acervo General	RS189.5 C4 1997	Disponible	Préstamo interno (etiqueta naranja)		023210

Explores the chromatographic methods used for the measurement of drugs, impurities, and excipients in pharmaceutical preparations - such as tablets, ointments, and injectables. This title contains a table listing the chromatographic data of over 1300 drugs and related substances - including sample matrix analyzed and sample handling procedures.

Incluye referencias bibliográficas.

1. REGULATORY CONSIDERATIONS FOR THE CHROMATOGRAPHER (John A. Adamovics).--
I. Introduction.--
II. Impurities.--
III. Stability.--
IV. Method Validation.--
V. System Suitability Testing.--
VI. Product Testing.--
VII. Conclusion.--
References.--

2. SAMPLE PRETREATMENT (John A. Adamovics).--
I. Introduction.--
II. Sampling.--
III. Sample Preparation Techniques.--
IV. Conclusions.--
References.--

3. PLANAR CHROMATOGRAPHY (John A. Adamovics and James C. Eschbach).--
I. Introduction.--
II. Materials and Techniques.--
III. Detection.--
IV. Methods Development.--
V. Conclusion.--
References.--

4. GAS CHROMATOGRAPHY (John A. Adamovics and James C. Eschbach).--
I. Introduction.--
II. Stationary Phases.--
III. Hardware.--
IV. Applications.--
V. Conclusion.--
References.--

5. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (John A. Adamovics and David L. Farb).--
I. Introduction.--
II. Sorbents.--
III. Instrumentation.--
IV. Method Development.--
V. Conclusion.--
References.--

6. CAPILLARY ELECTROPHORESIS (Shelley R. Rabel and John F. Stobaugh).--
1. Introduction.--
II. Capillary Electrophoresis Formats.--
III. Instrumentation.--
IV. Methods Development.--
V. Conclusion.--
References.--

7. SUPERCRITICAL FLUID CHROMATOGRAPHY OF BULK AND FORMULATED PHARMACEUTICALS (James T. Stewart and Nirdosh K. Jagota).--
1. Introduction.--
II. Hardware.--
III. Application of SFC to Selected Bulk and Formulated Pharmaceuticals.--
IV. Conclusions.--
V. References.--

8. APPLICATIONS (John A. Adamovics).--
I. Introduction.--
II. Abbreviations.--
III. Table of Analysis.--
References.

PREFACE:
The first edition of Chromatographic Analysis of Pharmaceuticals was published in 1990. The past years have allowed me to evaluate leads that I uncovered during the researching of the first edition, such as the first pub lished example of the application of chromatography to pharmaceutical analysis of medicinal plants. This and other examples are found in a rela tively rare book, Uber Kapillaranalyse und ihre Anwendung in Pharmazeu tichen Laboratorium (Leipzig, 1992), by H. Platz. Capillary analysis, the chromatographic technique used, was developed by Friedlieb Runge in the mid-1850s and was later refined by Friedrich Goppelsroeder. The principle of the analysis was that substances were absorbed on filter paper directly from the solutions in which they were dissolved; they then migrated to different points on the filter paper. Capillary analysis differed from paper chromatography in that no developing solvent was used. We find that, from these humble beginnings 150 years ago, the direct descendant of this technique, paper chromatography, is still widely used in evaluating radio pharmaceuticals.

This second edition updates and expands on coverage of the topics in the first edition. It should appeal to chemists and biochemists in pharma ceutics and biotechnology responsible for analysis of pharmaceuticals. As in the first edition, this book focuses on analysis of bulk and formulated drug products, and not on analysis of drugs in biological fluids.

The overall organization of the first edition-a series of chapters on regulatory considerations, sample treatment (manual/robotic), and chro matographic methods (TLC, GC, HPLC), followed by an applications sec tion-has been maintained. To provide a more coherent structure to this edition, the robotics and sample treatment chapters have been consolidated, as have the chapters on gas chromatography and headspace analysis. This edition includes two new chapters, on capillary electrophoresis, and super critical fluid chromatography. These new chapters discuss the hardware behind the technique, followed by their respective approaches to methods development along with numerous examples. All the chapters have been updated with relevant information on proteinaceous pharmaceuticals. The applications chapter has been updated to include chromatographic methods from the Chinese Pharmacopoeia and updates from U.S. Pharmacopeia 23 and from the British and European Pharmacopoeias. Methods developed by instrument and column manufacturers are also included in an extensive table, as are up-to-date references from the chromatographic literature.

The suggestions of reviewers of the first edition have been incorpo rated into this edition whenever possible. This work could not have been completed in a timely manner without the cooperation of the contributors, to whom I am very grateful.

John A. Adamovics.

Área de Ciencias de la Salud

Texto en Inglés.